Point of Care diagnostics for the analytes detection in liquid matrices

overview

OR-EL Organska Elektronika doo has developed and patented an innovative 

Point of Care (PoC) platform for the detection of analytes in liquid matrices. 

It has been successfully demonstrated in human (flavi virus detection), veterinary (African swine fever) and food (bacteria, toxins) fields of application. 

The POCOREL platform adopts Organic LED (OLED) for fluorescence excitation; 

it is currently available as advanced prototype (TRL = 7 / 8). 

The sample to be analysed is spotted on a low-cost plastic cartridge; the results are available in 10 to 30 minutes. 

The first product has been developed for the detection of toxins in Food.

advantages

POCOREL portable reader

The POCOREL diagnostic platform offers several advantages. Main features include:

• multi-parametric

• highly sensitive

• quantative

• low-cost

• rapid 

making it a portable diagnostic tool.

A low-cost plastic slide is factory pre-spotted with different biological probes: antigens, antibodies or small oligonucleotides sequences.

All the needed reagents are factory pre-loaded into the same low-cost slide, including the waste reservoir.

POCOREL slide is environment friendly. The User just need to load the sample into the specifically provided reaction chamber and follow the procedure steps, which may include a short incubation using the specifically provided Incubator. 

Currently, the results are obtained using the POCOREL portable Reader using the associated laptop PC. 

bibliography

1. Biosensors and Bioelectronics 46 (2013)44–47

   1. P. Melpignano et al. "A deep-blue OLED-based biochip for protein microarray fluorescence detection"

2. Biosensors and Bioelectronics 66(2015)271–276

3. P. Melpignano et al."OLED-based DNA biochip for Campylobacter spp. detection in poultry meat samples"

4. Journal of Microelectronics, Electronic Components and Materials, Vol. 46, No. 4(2016), 250 – 256

5. P. Melpignano et al. “Multi parametric Oled-Based Biosensor for Rapid Dengue Serotype Recognition With a New Point-Of-Care Serological Test”

6. Int. J. Numer. Meth. Biomedical Engineering, 2018:34:e2932 

7. P. Melpignano et al. "Image enhancement variational methods for enabling strong cost reduction in OLED based point of care immuno-fluorescent diagnostic systems"

8.  

9. Proceedings CMBBE 2018,P.R. Fernandes and J.M. Tavares (Editors) 

10. P. Melpignano et al. "Point of care OLED-based multiparametric biochip exploiting advanced image processing for Dengue Serotype recognition”

11. IEEE Transactions on Instrumentations and Measurements, DOI 10.1109/TIM 2020.2973913  

12. A. Samore’, P.Melpignano et al. “BrightNet: A deep CNN for OLED based point of care immunofluorescent diagnostic system”

13. Food Control 113 (2020) 107179 

14. P. Melpignano et al. “An OLED-based genosensor for the detection of Hermetia illucens in feeds”